HELP
Search Function
- The homepage displays the data content stored in the SASdb database.
- In the central search box, users can perform gene search or tissue search functions, and then access the detailed pages of the target gene or target tissue.
Gene Detail Page
- In the detail page of gene, taking FAM3A as an example, SASdb first present the basic information of this gene, including symbol, location, gene type, etc., and provide a visual representation of the gene structure.
- Users can browse all the transcript information related to FAM3A through a table. Subsequently, through a dual-coordinate bar chart, users will understand the statistical distribution of different types of ASE detected by FAM3A in various tissues, as well as the number statistics of DASEs.
- To further study the DASEs related to FAM3A, users can browse the detailed information of each DASE, as well as the related visualization results and the results of gender difference analysis. As shown in the figure, in an ASE type of SE detected by FAM3A (ASE ID: chrX@-@154512822^154511871-@154512822^154512411-154512313^154511871-), there are 16 transcripts with two splicing results, and this ASE shows a significant gender difference in the putamen.
Tissue Detail Page
- In the detail page of tissue, taking kidney as an example, users can first view the basic statistical information, including the number of ASEs detected in the kidney (150,928), the number of DASEs (309), and the number of related differentially expressed genes (241), etc.
- The page presents the distribution of the 5 types of ASEs detected in the kidney across various chromosomes through a bar chart.
- Users can browse the sample information of all kidney samples in the SASdb through the sample list table.
- To further explore the molecular functions related to sex-biased ASEs in kidney, the page displays the results of KEGG and GO enrichment analysis based on 241 differentially expressed genes. Users can browse the information of all significant pathways and terms that are enriched, and by clicking on the collapsed tree nodes, they can expand the related gene list.
